In this blog article find many guidelines to prepare your Mac for your live performance.
Link: Gig Performer | Optimize your Mac for a Gig
All tested on macOS Monterey.
I’ll also index all additional tips and tricks in this post (as for the Windows optimization guide).
Here’s a nice motto from this YouTube video: You learn 'cause you’ve been burned .
Index of other tips, found across the Community
 Speed up your workflow by automatically disabling/enabling sleep, screensaver and standby when Gig Performer is started/closed (link)
 High Sierra script that disables system processes in the Recovery Mode (link)
 Another workflow automation - enables the “Music” focus mode, deactivates Wi-Fi, Bluetooth, Time Machine, and opens Gig Performer (link)
 Sometimes on mid 2012 MBP, closing a Firefox Youtube tab ‘unlatches’ the Quantum 2626 driver. Use Brave instead (link)
 Nemanja’s preferences - (less is more)
 Try different audio interface (link)
 Use TurboBoost to prevent your Mac from going too fast and get too hot. (link)
 Review your plugins! Examples: BX3.
 Create a new user account. (link)
 Bluetooth issues when it is too hot (link)
 Known glitches when ZOOM is using an audio interface at the same time as Gig Performer (link)
 For Blackhole users: check if the Blackhole is listed as the ‘Clock Source’ (link).
 Second/backup graphics card (which gets used when you have low battery) can cause clicks/pops → Turn off ‘Automatic Graphics Switching’. LINK