For users of Jam Origin’s MIDI Guitar 2
You might want to consider to use the standalone version of MIDI Guitar 2.
This way MIDI Guitar 2 runs in a completely separate space and your CPU is able to offload its processing out of your normal audio process thread which helps with the overall performance. Additionally, this will allow you to globally adjust the desired options in MIDI Guitar 2. Some references: this, this, and this post.
Also make sure to check this post by Tony Geballe where he explains how to extend the low end of your guitar range for MIDI Guitar 2 using Gig Performer.
Another tip for users that want to use MIDI Guitar 2 in the Global rackspace → LINK
MIDI Guitar in another instance → LINK