While I agree with what pianopaul said, you won’t really know until you try it.
Even though different instances will run on different cores, when audio starts glitching on windows it’s rarely (in my experience) because the core the audio is running on is over its limit.
On my main audio system, for example, I get random glitching if I run my monitor (4K res) at 60 Hz. At very light load it won’t glitch. But running a DAW or any other ASIO audio app with a buffer around 64 samples will periodically glitch. Might be once every 5 minutes, but it’s there and it’s annoying. Change the refresh rate to 30 Hz and the problem goes away.
Give it a try, and if you start getting crackling the hard part is figuring out what’s really causing it and whether it’s something you can address.