Hi @Zipdog - one thing you could look into is temporarily downgrading the PCIE bus speed in the BIOS. I had a new PC build which suffered intermittent crackles and pops, despite being a beast with great latencyMon figures - and changing the buffer settings did nothing to fix the issue. Turned out the higher clock speeds were causing interference and changing the settings to a lower Generation fixed things completely.
Just an idea if your experiencing random crackles and pops, despite good specs. Happy to give more details if needed