There are lots of hidden settings in windows 10 regarding usb sleep and power modes.
Also found when playing both my keyboards aggressively that the usb connectors would cause a data loss so I hot glued all usb connectors in. ( my rig is all self contained in a dual manual custom built rig, so all I move is keyboard and another).
Not lost any usb since.
Incidentally when audio player was breaking up I notice that all MIDI was still sending output and GP had not flashed up audio disconnected when I lost audio output
Strange thing is when I lost audio tried reboot GP twice and rebooted computer twice no joy. The only way audio would work was by disconnecting mains for 3 mins then all worked fine