Audio glitches, even with no plugins loaded

Yes, it still occurs at 128, but it is much reduced.

I am not using Rosetta.

Any chance you are running low on battery?Please do a test and uncheck your audio input device

I bet this will fix the problem.
(btw. this is not allowed on Windows)

Other Mac tips: [blog] Optimize your Mac for a gig

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This was the solution. Once my replacement headphones arrived, I was able to use the interface’s out put, and using the output enabled me to use a whole whack of plugins at once on 16 samples without any glitches whatsoever in my performance and when using other software, like YouTube on a browser. Thank you!

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Great!

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Curious. Why are you using such a small buffer size? You’re really just making your computer work harder with no clear benefit that I can think of