Hey there,
Is this possible to have GP and Ableton opened and for exemple use Ableton only to trigger midi to hardware synth (with novation launch pro), GP to control 1 or 2 master keyboards.
Yep, absolutely!
You’ll only run in to issues if you have both GP and Ableton reacting to the same MIDI messages - e.g. if CC10 is assigned to both a slider in GP and a knob in Ableton then when that CC is received it will adjust both at the same time. Unless that’s what you want it to do of course!
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I had them both open on the same computer yesterday because I couldn’t export my audio from Ableton Live the way I wanted (first time I used it 
). So, I used GP to record the Ableton output via an audio loopback. It worked fine.
Thank you !!!
No problem about cpu usage of both ?
As a general rule, no problems.
However ultimately it depends how you use them - if both are heavily plugin laden you are probably going to start seeing some issues. However if I have read your use case fine and are sending out MIDI from live to an external synth - so using it like a sequencer essentially - you will have no issues.
Myself and many others run Live alongside GP all the time and have no issues. I use GP as a complete guitar amp/FX modelling platform so it’s relatively plugin heavy, and then Ableton is mainly running backing tracks/clicks with the occasional soft-synth as well. I have absolutely no problems running those two together 
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Thank you !!