My 2c having used or tried more or less all of the major guitar plugin suites over the years…
They can all produce sounds anywhere from fantastic to garbage, depending on how adept you are at figuring out what it is about the sound you’re hearing you do or don’t like, how to change it, and what your personal taste is.
I settled on TH-U primarily because I liked how the VST parameter interface worked with GP better than the others. Specifically, let’s say I build a TH-U rackspace with an amp, chorus, and distortion; then I link widgets to Amp Gain, Amp Bass/Mid/Treble, Overdrive Tone, Overdrive Gain, etc. In that rack I have Marshall JCM800 and a Tube Screamer. I have all my widgets set up and they’re working.
Now I copy that rackspace to a new one. I swap the Marshal amp for a Fender Twin and swap the Tube Screamer for an SD-1. All my widgets are still properly attached to their parameters. I don’t have to reconnect everything.
That’s not how most of the other guitar plugin suites worked historically, although some seem to be picking up on that ability. With most of them, if you change your Amp you need to re-connect all your widgets. (Although I think some are starting to get better about keeping parameters linked.)
At various times in the past I’d tell myself “just pick one amp, one distortion, one chorus, one reverb, and get on with playing. Stop messing around with endless combinations.” But I’ve come to accept that I seem to enjoy messing with endless combinations. I picked TH-U largely because it makes that easier and faster for me.
That aside, with all of them I’ve found presets that sound awesome with one guitar and total garbage with another. I go back and forth between a Strat and a PRS and generally use different racks/variations for them. That reinforces my desire to copy rackspaces, swap amps and fx, and not have to re-link every widget every time.