In this video is showcased a hybrid live setup for streaming Rocksmith. The author of this video also uses this for music production as well.
From 10:40 is the software side of the story, where Gig Performer kicks in.
He uses Voicemeeter to route audio, and has also incorporated StreamDeck into his setup.
The narrative is in funny Twitch-like manner, but don’t be tricked - this setup is highly flexible and sounds great.