You should have a look at this free PDF guide: https://www.cantabilesoftware.com/glitchfree/
Regarding your audio interface have a look here: Problems with Steinberg UR22-MkII
It ended up with a MOTU M2.
And finally, if you are giging a lot professionally, I can only recommend you to have a look at RME (FIreFace UCX or eventually BabyFace Pro). It is not the same price, but the hardware and drivers are at the top.