With a hex pickup, it is possible to route separate strings to different audio plugins.
For MIDI, in the case of routing the 6th and 5th string separately, you will have to use MIDI hardware.
Otherwise you can use a standard guitar without hardware with the Midi Guitar plugin.
It works by frequency detection, not string detection. So you can route a selected range of bass (or any other) keys separately to different MIDI channels (If you are familiar with the Boss OC-3 octaver, it works exactly the same way for selecting octave notes).
No more guitar amp here. It’s GP, laptop, S-gear, and some quality VST3s. I also run my old Roland GR-1 guitar synth (bought it in '93) through GP as well. I use one of the smaller HeadRush FRFR speakers for my onstage monitor and it sounds great and can get plenty loud if the need arises. I also run an electrified violin through GP with a few VSTs to maintain a decent level and good tone. When I use the violin all of the guitar VST3s are bypassed, and vice-versa. I’m happy with this set up.