Midi Guitar sometimes requiring GP restart

I know this is not a GP issue but I thought some may have had a similar experience with MG or another plug in.

I have Midi Guitar 2 in my Global rackspace to trigger soft synths.

I notice that if I change audio settings or import a rackspace that midi guitar disables requiring a reload or in some cases a restart.

Any idea why and if not, any other possibilities to reactivate besides reloading gig file or worse restarting the program?

Thanks

MM