If the external gear would be a plugin, that would actually be the case, right?
I would not use a plugin which would introduce 10 ms latency
It introduces 5 or less depending on your sample buffer.
Works perfectly fine in ableton.
Sounds like this is the solution
I’m curious. What effects are you using that are not available as VSTs?
The pedals are listed in my original post.
Microcosm, chroma console, chase bliss onward, and sloer reverb.
And are these really so unique that they couldn’t be replaced with a few VSTs?
I mean there are plenty of granular effects, multi-effects, loopers and certainly hundreds of reverb plugins out there.
Are these effects pedals that unique that you couldn’t find reasonable plugin replacements?
Had a feeling people were gonna start to rag me for having a hybrid rig lol here we go.
An external audio effect plugin is basic stuff. Just about every other vst host has it.
And yes they are. I did my research and didn’t find software plugins that I liked as well as I do these.
Plus I “play” the pedals live.
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Either way I really enjoyed GP, but with this rig iteration looks like I’ll have to move away from it. 
I don’t think we want to talk you out of this setup. But sometimes there are avenues to explore which people forgot just because they’re focusing on one particular solution.
More on topic: do you suggest a plugin that’s running as an extension of GP, but in the external pedal (thus possibly having more knowledge of latency, etc)?
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No, the plug-in I’m suggesting is a utility that routes audio from a set of outputs back into a set of inputs, automatically accounting for round-trip driver latency, and allowing you to adjust manually for any hardware latency.
I did go down the software path, but really just fell in love with the hardware. Obviously the Reverb is very irreplaceable, but the other pedals not so much in what they do.
also, several of the software plug-ins that did something similar weren’t built for live use, and had too much of a sample buffer built-in, causing too much latency.
Very replaceable
Nobody is ragging you…lots of people have hybrid rigs. Just curious.
As far as your particular issue is concerned, our resident expert on latency issues is out of town and will be back next week. He runs a hybrid setup as well and will no doubt have some insights.
Appreciate that! Thank you 
I built a hybrid rig that’s not as complicated as yours; it’s just guitar → pedals → interface → DAW/GP. I have played with the idea of getting them into the digital path, as a kind of effects loop. It’s pretty standard in the physical mixer world as I understand it, but to implement it on a computer, you need an audio interface with at least one extra pair of in/out channels to route as a send/return bus. In addition, as I understand it, you need a line-level controller, aka “ReAmp Box” or similar, to translate the analog audio signal out of the computer, through the board, and back into the computer, to the correct levels. Do you have those devices?
I’ve built that part in my head, but never actually put it together. In any event, I suppose I assumed that round-trip time would be whatever it is and would be part of how it would happen in an analog world; in other words, I thought it’d be insignificant. Perhaps I’m wrong there?
I also feel like that might be better handled at the hardware level, if possible, or at least as close to the interface as possible.
The idea of putting some software in a box to keep analog time with an upstream source is a compelling one. Would that have to be based on a shared MIDI clock or other time of time code?
Another idea is, do you have to go back into GP from the pedalboard? If you’re only concerned with a live scenario i think just going from GP to an interface out(s), to the pedalboard, probably to a DI box to go to the house. Does that make sense?
I also feel that going from GP into a DAW does induce its own latency but it’ll also be in sync with itself anyway, if that makes sense… you’d be recording “wet”, which i think would be a good thing unless you really need to tweak details after the fact. (I find i actually get to “done” if i don’t get stuck twiddling the knobs after the fact. My style is live improv, not pre-arranged music, so none of this may apply, YMMV.
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you’d need a line level converter to go from the interface OUT to the pedalboard IN, for sure.
I’ve got all that stuff managed. I use a line level pedal at front of signal change to adjust gain.
For recording I use a different process to record wet and dry separately.
This is for live use.
I don’t want the pedal board hardwired into my signal chain between interface and DI because I need optionality. I don’t want all my keyboards to run through it all the time.
So I’m sending and returning from separate outputs on the interface
Also, from what I understand - No latency is induced when using GP relayer.
Front of signal chain