I went to Tahoe 27 on Day 1 and noticed some [not all] of my Motu M2 GP 5.3.3 projects on my M4 were exhibiting some minor / random glitching / crackle etc… for the first time.
Please IGNORE this if you are not affected by this.
Did a bit of hunting around and found a quick 2 step fix.
-> re-install the MOTU [or your driver] - reboot
-> go to Terminal and run " sudo renice -20 $(pgrep coreaudiod) " … this will increase the Priority of CoreAudio - reboot