Yes, it still happens when starting up with Shift held, and happens with a new or empty gig. And everything (windows, drivers) is updated. And it’s a very clean audio-only PC.
I’ll try killing the antivirus stuff at the service level. I only considered it because another poster said he was having a similar problem with a different Focusrite interface, and that shutting off his Kaspersky seemed to address it. [This thread: [Solved] GP3 crash with sample rate changes] (I’m only running the standard stuff Microsoft puts in Windows.)