I’m running 3 instances of gig performer, lots of sample tank backspaces loaded, Guitar Rig, and the 3rd instance recording 18 tracks and processing vocals with Waves Autotune Real Time. At the end of the first set, my piano samples transposed. I think it may have even been a different transpose interval depending on which midi channel. I ruined my bands performance.
I think I may have just had too much going on as I had done this with 2 computers before. But one fell of the stage and damaged the screen recently. Gigging can be a rough business.
I am using a cooling fan under the computer and it was running. I restarted gig performer, went down to recording only 2 tracks (instead of 18) and it lasted the rest of the night.